The 52-year-old, who hosts the ITV breakfast show with Susanna Reid, says his 3.30am wake-up call is making him a “complete zombie”.
Speaking to the Mirror, Piers said he’s in bed before 9pm but often struggles to sleep and feels awful as he heads into work to be on air for 6.30am.
He said: “I woke up at 1am, 2am, and then 3am I got up and watched TV, so you basically become a complete zombie.
“I bumped into Sophie Raworth at the Chelsea Flower Show and she did it for two years on BBC Breakfast with Jeremy Bowen and she told me he actually thought he was dying.
“He had all these tests, and he thought he had cancer. It turned out it was just getting up at 3.30 in the morning.
“The moment he stopped doing the show, the pain went away.
“Literally, it was killing him.”
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Piers has been married to Celia Walden since 2010 and the couple have a five-year-old daughter Elise together.
He was previously married to Marion Shalloe and the couple had three boys, Albert, 16, Stanley, 20, and Spencer, 23.
The dad-of-four admitted he’s worried about how his strenuous schedule is damaging his health.
He added: “It’s killing me before my very eyes. It’s the least healthy existence imaginable.
“Your immune system gets crushed, you pick up every bug going, I’ve basically been ill for the entire 18 months in some form.
“You have about 18 breakfasts before midday, so everything is terrible about it except the show itself.”
While he has no plans to quit the GMB sofa just yet, Piers says his “body is screaming in pain at the moment”.
He said: “I’ll stay ’til death. If I die, it won’t continue much longer.
“My wife has no sympathy because she’s been up three times a night for the entire duration of our five year old daughter’s life, so I’m aware people have to get up for work early and do night shifts and so on.
“If you haven’t done it, let me tell you, it never gets easier, it just gets worse.
“Every day is a new horror.”
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